Article

CAN-TGI: Confidence-Aware Negative Sampling for Predicting TF-Target Gene Interaction via Heterogeneous Biological Networks Embedding

2025-08-20

Abstract excerpt

<title>Abstract</title> <p>Identifying transcription factor (TF)-target gene interactions is essential for understanding gene regulatory networks and disease mechanisms. Recent advances in network embedding have enabled more effective extraction of both structural and semantic information from TF-target gene interaction networks. However, a major challenge persists: the severe imbalance between known (positive) i...

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Literature Corpus work: 2365641e-25ec-542f-ab6e-3d990e9a7123
DOI: 10.21203/rs.3.rs-7323024/v1

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CAN-TGI: Confidence-Aware Negative Sampling for Predicting TF-Target Gene Interaction via Heterogeneous Biological Networks EmbeddingDOI 10.21203/rs.3.rs-7323024/v1Read

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