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Article

Global-local aware Heterogeneous Graph Contrastive Learning for multifaceted association prediction in miRNA-gene-disease networks.

Briefings in bioinformatics - 25 Jul 2024

Si Yuxuan, Huang Zihan, Fang Zhengqing, Yuan Zhouhang, Huang Zhengxing, Li Yingming, Wei Ying, Wu Fei, Yao Yu-Feng

Abstract excerpt

Unraveling the intricate network of associations among microRNAs (miRNAs), genes, and diseases is pivotal for deciphering molecular mechanisms, refining disease diagnosis, and crafting targeted therapies. Computational strategies, leveraging link prediction within biological graphs, present a cost-efficient alternative to high-cost empirical assays. However, while plenty of methods excel at predicting specific...

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PMID: 39256197
DOI: 10.1093/bib/bbae443
PMCID: PMC11387071

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