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Article

ERFMTDA: Predicting tsRNA-disease associations using an enhanced rotative factorization machine.

PLoS computational biology - 1 Aug 2026

Lan Wei, Wang Dong, Chen Wenyi, Yan Xuhua, Chen Qingfeng, Pan Shirui, Pan Yi

Abstract excerpt

tRNA-derived small RNAs (tsRNAs) have emerged as a novel class of regulatory molecules implicated in the pathogenesis of numerous human diseases, positioning them as promising biomarkers and therapeutic targets. Existing computational methods provide a cost-effective alternative to experimental method, but they tend to ignore biological attributes and complex feature interactions. To overcome these limitations,...

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PMID: 42611903
DOI: 10.1371/journal.pcbi.1014594
PMCID: PMC13485048

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