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Bruceine D targets PIK3R2 to block PI3K/AKT signaling and suppresses hepatocellular carcinoma progression

2026-08-28

Abstract excerpt

<i>Background: </i>Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies worldwide, with limited therapeutic options largely attributed to tumor recurrence, drug toxicity, and acquired resistance. <i>Purpose: </i>Bruceine D (BD), a quassinoid derived from Brucea javanica, was evaluated for its anti-HCC activity and underlying mechanisms using integrated approaches. <i>Study design: </i>Combine...

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Literature Corpus work
22df5c64-f628-56b3-b3ae-e9ac466e73b1
DOI
10.22541/authorea.15007999/v1
Open publication

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Bruceine D targets PIK3R2 to block PI3K/AKT signaling and suppresses hepatocellular carcinoma progressionDOI 10.22541/authorea.15007999/v1
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