Article

Wnt/β-catenin pathway is a key signaling pathway to trastuzumab resistance in gastric cancer cells

2023-05-26

Abstract excerpt

Backgroud: Trastuzumab is the only approved target agent for the first-line treatment of human epidermal growth factor receptor-2 (HER-2) positive gastric cancer; however, trastuzumab resistance is a major problem in clinical practice. To comprehend the mechanism of trastuzumab resistance, we focused on the Wnt/β-catenin signaling pathway and its influence on the phenotypes and behavior of trastuzumab-resistant g...

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Literature Corpus work: 22991c59-ad5f-5d71-a5bd-77a4472125c1
DOI: 10.21203/rs.3.rs-2946372/v1

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