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Article

Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells.

Molecular cancer research : MCR - 1 Dec 2012

Wu Yanyuan, Ginther Charles, Kim Juri, Mosher Nicole, Chung Seyung, Slamon Dennis, Vadgama Jaydutt V

Abstract excerpt

To understand the mechanisms leading to trastuzumab resistance in HER2-overexpressing breast tumors, we created trastuzumab-insensitive cell lines (SKBR3/100-8 and BT474/100-2). The cell lines maintain HER2 receptor overexpression and show increase in EGF receptor (EGFR). Upon trastuzumab treatme...

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Source

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Identifiers

PMID: 23071104
DOI: 10.1158/1541-7786.MCR-12-0155-T
PMCID: PMC3732195

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23071104-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells.PMID 23071104Read ↗

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