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HadoopCNV: A dynamic programming imputation algorithm to detect copy number variants from sequencing data

2017-04-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Whole-genome sequencing (WGS) data may be used to identify copy number variations (CNVs). Existing CNV detection methods mostly rely on read depth or alignment characteristics (paired-end distance and split reads) to infer gains/losses, while neglecting allelic intensity ratios and cannot quantify copy numbers. Additionally, most CNV callers are not scalable to handle a larg...

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Literature Corpus work: 227f538a-f24a-5103-9cad-5e382716ffe2
DOI: 10.1101/124339

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