Article

SARS-CoV-2 mechanistic correlates of protection: insight from modelling response to vaccines

2021-11-01

Abstract excerpt

The definition of correlates of protection is critical for the development of next generation SARS-CoV-2 vaccine platforms. Here, we propose a new framework for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics and data mining of immunological markers. The application to three different studies in non-human primates evaluating SARS-CoV-2 vaccines based on CD40-targe...

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Literature Corpus work: 222f3f9a-fa08-5a28-912f-b85a2ccff9b7
DOI: 10.1101/2021.10.29.466418

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