Article

Correlates of protection against SARS-CoV-2 shedding in a controlled human infection study in immune-experienced participants

2026-07-27

Abstract excerpt

<title>Abstract</title> <p>Defining immune correlates associated with protection from detectable infection with SARS-CoV-2 remains a key question in the design of next-generation vaccines, yet the immune responses that prevent early viral replication after exposure remain incompletely defined. Here, we describe detailed immunological findings from a SARS-CoV-2 controlled human infection model in 48 healthy partic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36d6f411-4331-5513-81b5-6173a6a57d4d
DOI: 10.21203/rs.3.rs-10438183/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Correlates of protection against SARS-CoV-2 shedding in a controlled human infection study in immune-experienced participantsDOI 10.21203/rs.3.rs-10438183/v1Read

Mucosal and Systemic Immune Correlates of Viral Control following SARS-CoV-2 Infection Challenge in Seronegative AdultsSemantic proximity Read

Biomarkers of protection against controlled human SARS-CoV-2 Delta variant breakthrough infectionSemantic proximity Read

Clinical and immunological features of SARS-CoV-2 breakthrough infections in vaccinated individuals requiring hospitalizationSemantic proximity Read

Observational Report on Functional SARS-CoV-2 Immune Responses in Immune Competent and Compromised IndividualsSemantic proximity Read

Clinical course impacts early kinetics and long-term magnitude and amplitude of SARS-CoV-2 neutralizing antibodies beyond one year after infectionSemantic proximity Read

Cohort Profile: The Danish National Cohort Study of Effectiveness and Safety of SARS-CoV-2 vaccines (ENFORCE)Semantic proximity Read

SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunitySemantic proximity Read

Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infectionSemantic proximity Read

Antibody response to SARS-CoV-2 infection in humans: a systematic reviewSemantic proximity Read

Neutralizing antibody titers predict protection from virus transmission in a cohort of household members with documented exposure to SARS-CoV-2Semantic proximity Read

Antibody Responses In Non-Severe SARS-CoV-2 Infections Are Driven By CD4+ T cells and AgeSemantic proximity Read

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccinationSemantic proximity Read