Article

RNA processing kinase inhibitors and epigenetic inhibitors in combination with oncology drugs or investigational agents in multi-cell type patient-derived tumor cell line spheroids

2025-05-15

Abstract excerpt

<title>Abstract</title> <p>The alternative splicing of mRNA precursors allows one gene to yield multiple proteins with distinct functions. CDC-like kinases (CLKs) serve as pivotal regulators of alternative splicing. Control of protein expression also occurs at the level of DNA through histone methylation and demethylation. We investigated the activity of two CLK inhibitors, cirtuvivint and CC-671, and the LSD1 in...

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Literature Corpus work: 220e4057-92e9-5bf9-91cd-e2eddfe6eba3
DOI: 10.21203/rs.3.rs-6602839/v1

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