Article

Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding

2022-08-25

Abstract excerpt

The binding affinity of the SARS-CoV-2 spike (S)-protein ΔΔG bind to the human membrane protein ACE2 is critical for virus function and evolution. Computational structure-based screening of new S-protein mutations for ACE2 binding lends promise to rationalize virus function directly from protein structure and ideally aid early detection of potentially concerning variants. We used a computational protocol based on...

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Literature Corpus work: 21f358e1-b170-531f-bdc7-02d697cfaf6a
DOI: 10.1101/2022.08.25.505249

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