Article

Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism

2023-03-27

Abstract excerpt

Drug development is an expensive and time-consuming process, with only a small fraction of drugs gaining regulatory approval from the often many thousands of candidates identified during target validation. Once a lead compound has been identified and optimised, they are subject to intensive pre-clinical research to determine their pharmacodynamic, pharmacokinetic and toxicological properties, procedures which inev...

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Literature Corpus work: 21140de6-d466-5892-a711-874690e82a0e
DOI: 10.12688/f1000research.122987.2

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