Article

A Randomised Clinical Trial of the Safety and Pharmacokinetics of VRC07-523LS Administered via Different Routes and Doses (HVTN 127/HPTN 087)

2024-01-11

Abstract excerpt

<h4>Background</h4> Broadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the only bnAb HIV prevention efficacy studies to date, the Antibody Mediated Prevention (AMP) trials, a CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention efficacy against highly neutralization-sensitive viruses but was ineffective against less sensitive vi...

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Literature Corpus work: 2015a42e-cca8-5ef4-9dcf-267f53e2ac83
DOI: 10.1101/2024.01.10.23299799

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