Article

Light Chain Neurofilament to HDGFL2 cryptic peptide ratio as a fluid biomarker to monitor TDP-43 dysfunction in ALS and FTD

2026-01-02

Abstract excerpt

<h4>ABSTRACT</h4> TDP-43 proteinopathy is a neuropathological hallmark of nearly all amyotrophic lateral sclerosis (ALS) and approximately half of frontotemporal dementia (FTD) cases. Nuclear loss of TDP-43 leads to widespread RNA misprocessing, such as the inclusion of cryptic exons that are no longer repressed by TDP-43. Notably, in-frame cryptic exons encode novel cryptic peptides that can be detected in biofl...

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Identifiers and source

Literature Corpus work: 1f867617-62b0-5567-b7ab-628b708901ce
DOI: 10.64898/2025.12.30.25343222

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