Article

Kar4, the Yeast Homolog of METTL14, is Required for mRNA m <sup>6</sup> A Methylation and Meiosis

2023-01-29

Abstract excerpt

KAR4 , the yeast homolog of the mammalian mRNA N 6 A-methyltransferase complex component METTL14 , is required for two disparate developmental programs in Saccharomyces cerevisiae : mating and meiosis. To understand KAR4 ’s role in yeast mating and meiosis, we used a genetic screen to isolate 25 function-specific mutant alleles, which map to non-overlapping surfaces on a predicted structure of the Kar4 protein...

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Literature Corpus work: 1eddac69-6b84-519a-bb25-46468ac29c8b
DOI: 10.1101/2023.01.29.526094

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