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Article

Therapeutic potentials of nonpeptidic V2R agonists for partial cNDI-causing V2R mutants.

PloS one - 1 Jan 2024

Kuramoto Ritsuki, Kise Ryoji, Kanno Mayu, Kawakami Kouki, Ikuta Tatsuya, Makita Noriko, Inoue Asuka

Abstract excerpt

Loss-of-function mutations in the type 2 vasopressin receptor (V2R) are a major cause of congenital nephrogenic diabetes insipidus (cNDI). In the context of partial cNDI, the response to desmopressin (dDAVP) is partially, but not entirely, diminished. For those with the partial cNDI, restoration of V2R function would offer a prospective therapeutic approach. In this study, we revealed that OPC-51803 (OPC5) and...

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Identifiers

PMID: 38748623
DOI: 10.1371/journal.pone.0303507
PMCID: PMC11095762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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