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Article

Membrane fluidity and epidermal growth factor receptor function in breast cancer

1998-01-01

Abstract excerpt

The epidermal growth factor receptor (EGFR) has been implicated in the growth and development of a number of human cancers including breast cancer. The activity and expression of membrane associated proteins such as the EGFR may be modulated by the physical state of the membrane. Activation of the EGFR depends on the lateral diffusion and dimerisation of receptor monomers. Changes in membrane fluidity may therefor...

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Literature Corpus work
1ecd0f01-02f4-5c13-bc1f-2c71dc8731ef
DOI
10.5525/gla.thesis.71574
Open publication

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