Article

ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons

2023-06-24

Abstract excerpt

Mutations in the AAA+ ATPase p97 (also known as valosin containing protein, VCP) cause multisystem proteinopathy 1 (MSP-1) which includes amyotrophic-lateral sclerosis (ALS); however, the pathogenic mechanisms that contribute to motor neuron loss in familial ALS caused by p97 mutations remain obscure. Here, we use two distinct induced pluripotent stem cell models differentiated into spinal motor neurons to investi...

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Literature Corpus work: 1ea11de9-9f1f-54e6-a7ba-a06c7702a19c
DOI: 10.1101/2023.06.21.545956

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