Article

Highly concentrated trehalose induces transient senescence-associated secretory phenotype in fibroblasts via CDKN1A/p21

2021-10-06

Abstract excerpt

Trehalose is the nonreducing disaccharide of glucose, evolutionarily conserved in invertebrates, but does not exist in vertebrates. The living skin equivalent (LSE) is an organotypic coculture containing keratinocytes cultivated on fibroblast-populated dermal substitutes. We demonstrated that human primary fibroblasts treated with highly concentrated trehalose promote significantly extensive spread of the epiderma...

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Literature Corpus work: 1e71d61e-d73d-5fd9-bdb4-38962a107e7e
DOI: 10.1101/2021.10.06.463325

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