Article

SpaFun: Discovering Domain-specific Spatial Expression Patterns and New Disease-Relevant Genes using Functional Principal Component Analysis

2025-02-21

Abstract excerpt

SpaFun is a novel, non-model-based method developed to address limitations in existing spatially variable gene (SVG) detection techniques, particularly for large-scale spatially resolved transcriptomics (SRT) datasets. These limitations include computational inefficiency, limited statistical power with increasing data size, and the inability to capture spatial heterogeneity and co-expression patterns among genes....

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Literature Corpus work: 1e1737ec-71eb-5287-aaba-0c31eb1d27ed
DOI: 10.1101/2025.02.17.638766

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