Article

<i>DESpace2</i> : detection of differential spatial patterns in spatial omics data

2025-07-02

Abstract excerpt

Spatially resolved transcriptomics (SRT) enables the investigation of mRNA expression in a spatial context. While several SRT analysis frameworks have been developed, the vast majority of them focus on analyzing individual samples, and do not allow for comparisons of spatial gene expression patterns across experimental conditions, such as healthy vs . diseased states. Here, we present an approach to identify so-c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3da1d70-83cd-5574-aaf5-211a37453037
DOI: 10.1101/2025.06.30.662268

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>DESpace2</i> : detection of differential spatial patterns in spatial omics dataDOI 10.1101/2025.06.30.662268Read

scBSP: A fast and accurate tool for identifying spatially variable features from high-resolution spatial omics dataSemantic proximity Read

SOAR elucidates disease mechanisms and empowers drug discovery through spatial transcriptomicsSemantic proximity Read

Spatial pattern and differential expression analysis with spatial transcriptomic dataSemantic proximity Read

SpatialDEG: Identification of differentially expressed genes by leveraging spatial information in spatially resolved transcriptomic studiesSemantic proximity Read

Toward Computationally Complete Spatial OmicsSemantic proximity Read

Spatial Transcriptomics Arena (STAr): an Integrated Platform for Spatial Transcriptomics Methodology ResearchSemantic proximity Read

STcompare: comparative spatial transcriptomics data analysis of structurally matched tissues to characterize differentially spatially patterned genesSemantic proximity Read

SpaFun: Discovering Domain-specific Spatial Expression Patterns and New Disease-Relevant Genes using Functional Principal Component AnalysisSemantic proximity Read

MatriSpace: Identification and visualization of spatially resolved ECM gene expression patterns in health and diseaseSemantic proximity Read

Identifying Genes with Location Dependent Noise Variance in Spatial Transcriptomics DataSemantic proximity Read

GraphCompass: Spatial metrics for differential analyses of cell organization across conditionsSemantic proximity Read

A comparative study of statistical methods for identifying differentially expressed genes in spatial transcriptomicsSemantic proximity Read