Article

Efficient Precision Dosing Under Estimated Uncertainties via Koopman Expectations of Bayesian Posteriors with Pumas

2021-01-27

Abstract excerpt

Personalized precision dosing is about mathematically determining effective dosing strategies that optimize the probability of containing a patient’s outcome within a therapeutic window. However, the common Monte Carlo approach for generating patient statistics is computationally expensive because thousands of simulations need to be computed. In this manuscript we describe a new method which utilizes the Koopman o...

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Literature Corpus work: 1d2db2d9-2135-5db9-8995-e1ebc63b1b31
DOI: 10.1101/2021.01.25.428134

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