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Ovarian carcinoma patients with a tumor<i>BRCA</i>-like genomic copy number aberration profile benefit from maintenance olaparib/bevacizumab therapy in the PAOLA-1 randomized controlled trial

2023-06-01

Abstract excerpt

<h4>Background</h4> We previously established an ovarian carcinoma (OC) BRCA -like genomic copy number aberration profile classifier (“ BRCA -like classifier”), which identifies tumors with deleterious mutations and epigenetic alterations in the homologous recombination pathway (1). We explored whether the classifier may also be predictive for therapies targeting tumors with homologous recombination deficiency (HR...

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Literature Corpus work
1d28acb8-a851-5c3c-b50c-1cfd254ebe09
DOI
10.1101/2023.05.27.23290631
Open publication

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Ovarian carcinoma patients with a tumor<i>BRCA</i>-like genomic copy number aberration profile benefit from maintenance olaparib/bevacizumab therapy in the PAOLA-1 randomized controlled trialDOI 10.1101/2023.05.27.23290631
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