Article

Targeted internalization and activation of glycosidic switch liposomes by an EphA2 PEG engager increases therapeutic efficacy against lung cancer

2024-02-23

Abstract excerpt

Glycosidic switch liposome (GSL) technology uses a reversible glucuronide ester to efficiently encapsulate and stably retain potent anticancer drugs in liposomes. Parental drug is generated by enzymatic hydrolysis of the glucuronide switch in the lysosomes of target cells. Here we investigated if bispecific molecules simultaneously targeting polyethylene glycol (PEG) on GSL and an internalizing tumor antigen could...

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Identifiers and source

Literature Corpus work: 1d13eb8d-77b1-56a0-8a40-b1f6dca2a327
DOI: 10.21203/rs.3.rs-3938778/v1

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Targeted internalization and activation of glycosidic switch liposomes by an EphA2 PEG engager increases therapeutic efficacy against lung cancerDOI 10.21203/rs.3.rs-3938778/v1Read

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