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Myocardial-derived small extracellular vesicles spontaneously released from living myocardial slices under biomimetic culture conditions regulate contractility and cardiac remodelling

2024-02-12

Abstract excerpt

<h4>BACKGROUND</h4> Small extracellular vesicles (sEVs) released in the cardiac microenvironment are reported to regulate cardiac remodelling, partially via microRNA transfer. Harvesting sEVs produced exclusively from the myocardium remains challenging and a solid research platform for sEV cardiovascular testing needs to be established. Organotypic living myocardial slices (LMS) allow to mimic cardiac disease and...

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Literature Corpus work
1cd964c3-943d-5640-8319-05bd6980d309
DOI
10.1101/2024.02.09.24302607
Open publication

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Myocardial-derived small extracellular vesicles spontaneously released from living myocardial slices under biomimetic culture conditions regulate contractility and cardiac remodellingDOI 10.1101/2024.02.09.24302607
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