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Article

Enterovirus D68 B3 clade strains are efficiently recovered from cDNA infectious clones in 293T cells and infect human spinal cord organoids.

Journal of virology - 19 May 2026

Jones Jennifer E, Maya Sarah, Yovel Gal, Ciomperlik-Patton Jessica, Anstadt Jennifer, Freeman Megan Culler

Abstract excerpt

Enterovirus D68 (EV-D68) is associated with respiratory disease in children. Between 2014 and 2018, EV-D68 infection was linked to peaks of a polio-like neurologic condition called acute flaccid myelitis (AFM), but currently circulating strains are not. We hypothesized that specific mutations within B3 clade strains impact neurovirulence. Few studies have investigated B3 clade strains, and none have recovered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42037414
DOI: 10.1128/jvi.00450-26
PMCID: PMC13185614

Genes

AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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