Article

Using Historical Data to Facilitate Clinical Prevention Trials in Alzheimer Disease?

2021-02-23

Abstract excerpt

<title>Abstract</title> <p>BackgroundThe Placebo Group Simulation Approach (PGSA) aims at partially replacing Randomized Placebo-Controlled Trials (RPCTs) using data from historical control groups in order to decrease the needed number of study participants exposed to lengthy placebo treatment. PGSA algorithms were originally derived from Mild Cognitive Impairment (MCI) data of the Alzheimer's Disease Neuroimagin...

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Literature Corpus work: 1c2a4152-40d6-59de-a13f-817f01690254
DOI: 10.21203/rs.3.rs-236517/v1

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