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Article

Predictors of progression from mild cognitive impairment to dementia in the placebo-arm of a clinical trial population.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Prins Niels D, van der Flier Wiesje M, Brashear H Robert, Knol Dirk L, van de Pol Laura A, Barkhof Frederik, Scheltens Philip

Abstract excerpt

We studied the predictive value of cognitive performance, vascular risk factors, apolipoprotein E (APOE) genotype, and structural brain changes on MRI, on progression to dementia in post hoc analyses of 426 placebo patients (mean age 71 years; 55% women) with mild cognitive impairment (MCI) who participated in a previously published large multi-center clinical trial (Gal-Int-11). The ADAS-cog/MCI test, the New...

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PMID: 23563246
DOI: 10.3233/JAD-122233

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APOE

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