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Multidimensional Mechanistic Elucidation of Panax Notoginseng Saponins for Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo Validation

2026-07-02

Abstract excerpt

<title>Abstract</title> <p>Background Alcohol-induced osteonecrosis of the femoral head (AIONFH) is a prevalent orthopedic disease caused by chronic alcohol abuse, characterized by impaired femoral head perfusion, osteocyte necrosis and progressive structural collapse. Existing hip-preserving interventions yield limited efficacy, with most patients ultimately requiring total hip arthroplasty. Panax Notoginseng S...

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Literature Corpus work
1c0c8fbb-a045-5abe-a33f-6ba2f8fde573
DOI
10.21203/rs.3.rs-10193250/v1
Open publication

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Multidimensional Mechanistic Elucidation of Panax Notoginseng Saponins for Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo ValidationDOI 10.21203/rs.3.rs-10193250/v1
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