Article

Exploring Resistance to ETS Targeting Agents in Diffuse Large B-Cell Lymphoma

2025-09-20

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) remains a challenging disease with limited therapeutic options beyond standard immunochemotherapy. ETS transcription factors, including SPIB and SPI1, are implicated in lymphoma pathogenesis and can be targeted by the small molecule TK216, which disrupts ETS-DHX9 interactions. To explore mechanisms of resistance, we generated stable TK216-resistant clones from the ABC-DLBCL li...

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Literature Corpus work: 1b2a3bfd-b784-5654-9169-514703d53164
DOI: 10.1101/2025.09.18.675797

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