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Article

Atlas of human diseases influenced by genetic variants with extreme allele frequency differences.

Human genetics - 1 Jan 2017

Sulovari Arvis, Chen Yolanda H, Hudziak James J, Li Dawei

Abstract excerpt

Genetic variants with extreme allele frequency differences (EAFD) may underlie some human health disparities across populations. To identify EAFD loci, we systematically analyzed and characterized 81 million genomic variants from 2504 unrelated individuals of 26 world populations (phase III of the 1000 Genomes Project). Our analyses revealed a total of 434 genes, 15 pathways, and 18 diseases and traits influenced...

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Identifiers

PMID: 27699474
DOI: 10.1007/s00439-016-1734-y

Genes

EDAR
KRT71
KRT75
KRT83
LCT
NACA2
TRIM40

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