Article

Effective Aerosol Inoculation of Dose-Escalated Seasonal Influenza H3N2 Virus in Controlled Human Infection Model

2025-07-24

Abstract excerpt

Human challenge models (CHIMs) are instrumental in advancing influenza research but have traditionally relied on intranasal inoculation, which does not mimic the natural aerosol transmission of the virus. We conducted a dose-escalation influenza CHIM study to evaluate the safety and feasibility of two modern aerosol delivery systems: a flow-focusing monodisperse aerosol generator (FMAG) and a medical nebulizer. Fo...

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Identifiers and source

Literature Corpus work: 1ac4428b-5a5b-57e4-a66d-a8c0bd5495b4
DOI: 10.1101/2025.07.23.25332064

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