Article

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge

2022-02-01

Abstract excerpt

<title>Abstract</title> <p>To establish a novel SARS-CoV-2 human challenge model, 36 volunteers aged 18-29 years without evidence of previous infection or vaccination were inoculated with 10 TCID<sub>50</sub> of a wild-type virus (SARS-CoV-2/human/GBR/484861/2020) intranasally. Two participants were excluded from per protocol analysis due to seroconversion between screening and inoculation. Eighteen (~53%) became...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b5240a2-d612-5035-9eb9-d3891e3edea6
DOI: 10.21203/rs.3.rs-1121993/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Safety, tolerability and viral kinetics during SARS-CoV-2 human challengeDOI 10.21203/rs.3.rs-1121993/v1Read

A randomized, placebo-controlled trial of a nasal spray solution containing broadly potent neutralizing antibodies against SARS-CoV-2 variants in healthy volunteersSemantic proximity Read

Clinical and experimental factors that affect the reported performance characteristics of rapid testing for SARS-CoV-2Semantic proximity Read

Asymptomatic and presymptomatic transmission of SARS-CoV-2: A systematic reviewSemantic proximity Read

Epidemiology of Covid-19Semantic proximity Read

Trajectory of viral load in a prospective population-based cohort with incident SARS-CoV-2 G614 infectionSemantic proximity Read

Clinical evaluation of the Roche/SD Biosensor rapid antigen test with symptomatic, non-hospitalized patients in a municipal health service drive-through testing siteSemantic proximity Read

Viral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort studySemantic proximity Read

The evidence on transmission dynamics of COVID-19 from pre- and asymptomatic cases: protocol for a systematic review (Version 2)Semantic proximity Read

Longitudinal investigation of a single variant SARS-CoV-2-outbreak in the immunologically naïve population of Ulvik, NorwaySemantic proximity Read

Comparative performance of SARS CoV-2 lateral flow antigen tests demonstrates their utility for high sensitivity detection of infectious virus in clinical specimensSemantic proximity Read

Epidemiological Parameters of SARS-CoV-2 in the UK during the 2023/2024 Winter: A Cohort StudySemantic proximity Read

Performance of Lateral Flow Assays for SARS-CoV-2 Compared to RT-qPCRSemantic proximity Read