Article

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells <i>via</i> promoting heme synthesis

2023-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Loss-of-function mutations of ZBTB24 cause the Immunodeficiency, Centromeric Instability and Facial Anomalies syndrome 2 (ICF2). ICF2 is a rare autosomal recessive disorder with immunological defects in serum antibodies and circulating memory B cells, indicating an essential role of ZBTB24 in the terminal differentiation of B cells. Here we generated B-cell specific Zbtb24-deficient mice and sy...

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Literature Corpus work: 1a06e237-4a50-591c-8d3d-2f43b3dd6069
DOI: 10.1101/2023.12.23.573176

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