Article

Hypermethylated CACNB2 Predicts Poor Prognosis And Promotes Proliferation, Invasion and Apoptotic Resistance in Pancreatic Ductal Adenocarcinoma

2024-11-27

Abstract excerpt

<title>Abstract</title> <p>Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers and its 5-year survival rate is less than 10%. DNA-methylation emerges as a pivotal factor in the carcinogenesis, progression and chemoresistance of PDAC. However, numerous methylation-regulated genes and their tumor-promoting mechanisms remain largely unknown. Methods The TCGA database was anal...

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Literature Corpus work: 197e9992-db87-5792-ada4-e10cdeac67ab
DOI: 10.21203/rs.3.rs-5358116/v1

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