Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells

19 May 2018

Abstract excerpt

MicroRNA let-7 has been reported to be down-regulated in several human cancers and is now characterized as a tumor suppressor. IGF1R is over-expressed in many cancers and IGF1/IGF1R pathway is attractive target for anticancer therapy. However, the crosstalk between let-7 and IGF1/IGF1R are largely unknown. The present study showed IGF1R were significantly over-expressed in colorectal cancer tissues compared with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Growth Hormone and Insulin-like Growth Factors
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29886785
DOI: 10.1080/15384101.2018.1469873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cellsPMID 29886785Read ↗

Let‐7e enhances the radiosensitivity of colorectal cancer cells by directly targeting insulin‐like growth factor 1 receptorSemantic proximity Read ↗

Let-7c-5p Down Regulates the Proliferation of Colorectal Cancer Through the MAPK-ERK-Signaling PathwaySemantic proximity Read ↗

The molecular mechanisms and therapeutic potential of microRNA-7 in cancerSemantic proximity Read ↗

The insulin-like growth factor binding proteins 3 and 7 are associated with colorectal cancer and liver metastasisSemantic proximity Read ↗

MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptorSemantic proximity Read ↗

IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesisSemantic proximity Read ↗

Down-regulation of the let-7i facilitates gastric cancer invasion and metastasis by targeting COL1A1Semantic proximity Read ↗

Combined Inhibition of Insulin Growth Factor 1 Receptor and Autophagy impede Colorectal Cancer MetastasisSemantic proximity Read ↗

Insulin-Like Growth Factor-1 Signaling Regulates miRNA Expression in MCF-7 Breast Cancer Cell LineSemantic proximity Read ↗

FGF14 Functions as a Tumor Suppressor through Inhibiting PI3K/AKT/mTOR Pathway in Colorectal CancerSemantic proximity Read ↗

MicroRNA-7 directly targets insulin-like growth factor 1 receptor to inhibit cellular growth and glucose metabolism in gliomasSemantic proximity Read ↗

Targeting the IGF1 axis in cancer proliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.