Mendelian randomization analysis does not reveal a causal influence between lipoprotein(A) and immune-mediated inflammatory diseases

Abstract excerpt

<title>Abstract</title> <p>Observational studies have reported an association between lipoprotein(a) (Lp(a)) and immune-mediated inflammatory diseases (IMIDs). Here, we aimed to explore causal relationship between Lp(a) and IMIDs by Mendelian randomization (MR) analysis. We performed a two-sample mendelian randomization analyses based on genome-wide association study (GWAS) summary statistics of Lp(a) and nine IM...

Topics

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• Atherosclerosis and Cardiovascular Diseases
• Cholesterol
• Diabetes and associated disorders
• Genetic Associations and Epidemiology
• Liver Disease Diagnosis and Treatment
• Lupus Erythematosus, Systemic
• Mendelian Randomization Analysis
• Systemic Lupus Erythematosus Research

Identifiers and source

Literature Corpus work

1892e087-d965-51fc-8a6a-24977f5dc093

DOI

10.21203/rs.3.rs-4878166/v1