Article

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

2024-06-08

Abstract excerpt

Imbalances in lipid storage and secretion lead to the accumulation of hepatocyte lipid droplets (LDs) (i.e., hepatic steatosis). Our understanding of the mechanisms that govern the channeling of hepatocyte neutral lipids towards cytosolic LDs or secreted lipoproteins remains incomplete. Here, we performed a series of CRISPR-Cas9 screens under different metabolic states to uncover mechanisms of hepatic neutral lipi...

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Literature Corpus work: 18330d32-3f95-55b2-aa43-09850a243c53
DOI: 10.1101/2024.06.07.597858

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