Article

Systematic discovery of single-cell protein networks in cancer with Shusi

2025-04-28

Abstract excerpt

Context-specific protein-protein interaction (PPI) drive heterogeneity of primary tumor, forming a formidable challenge to effective cancer therapy. However, systematically mapping and modeling these interactions at single-cell resolution across diverse cancer types remains an unmet need. Here, we present Shusi, a large language model-enhanced variational graph auto-encoder model trained on over single cells acros...

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Literature Corpus work: 16a1a402-ef19-5534-91fa-9082c7e76c5d
DOI: 10.1101/2025.04.27.649905

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