[ ¹⁸ F]FLT-PET as predictive non-invasive biomarker for neoadjuvant therapy with Wee1 and ATR inhibitors

Abstract excerpt

<h4>ABSTRACT</h4> Besides immunotherapy, inhibitors of the DNA damage response (DDR) are currently one of the most promising contributors to improved cancer therapy. They exploit elevated replicative stress in cancer cells and often rely on synthetic lethality with existing gene deficiencies or between targeted pathways. In view of the absence of reliable histological biomarkers for replicative stress, this study...

Topics

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• BRCA gene mutations in cancer
• Cancer-related Molecular Pathways
• Cell death mechanisms and regulation
• DNA Repair Mechanisms
• Mitochondrial Function and Pathology
• PARP inhibition in cancer therapy
• Radiation Therapy and Dosimetry
• Radiomics and Machine Learning in Medical Imaging

Identifiers and source

Literature Corpus work

1662217a-c9c7-5fbd-bb0b-a5d2ae164ef8

DOI

10.64898/2026.03.10.710900