Article

Pharmacological rescue of the brain cortex phenotype of <i>Tbx1</i> mouse mutants: significance for 22q11.2 deletion syndrome

2021-02-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Tbx1 mutant mice are a widely used model of 22q11.2 deletion syndrome (22q11.2DS) because they manifest a broad spectrum of physical and behavioral abnormalities that is similar to that found in 22q11.2DS patients. In Tbx1 mutants, brain abnormalities include changes in cortical cytoarchitecture, hypothesized to be caused by the precocious differentiation of cortical progen...

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Literature Corpus work: 1600dea9-463f-5a61-874d-b005fc930ec2
DOI: 10.1101/2021.02.04.429794

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