Article

Tempo: an unsupervised Bayesian algorithm for circadian phase inference in single-cell transcriptomics

2022-03-18

Abstract excerpt

The circadian clock is a 24-hour cellular timekeeping mechanism that temporally regulates human physiology. Answering several fundamental questions in circadian biology will require joint measures of single-cell circadian phases and transcriptomes. However, no widespread experimental approaches exist for this purpose. While computational approaches exist to infer cell phase directly from single-cell RNA-sequencing...

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Literature Corpus work: 158e6c6e-b355-51f3-9acb-0498260dbe9f
DOI: 10.1101/2022.03.15.484454

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