Article

Trustworthy agentic genomics through versioned skill libraries

2026-06-15

Abstract excerpt

<h4>Summary</h4> Genomics is adopting autonomous AI agents that interpret genomes from natural-language instructions faster than it is building the means to trust them. We report the first large-scale controlled evaluation of where, in an agentic genomic pipeline, correctness must reside for the system to be trustworthy at clinical scale. Using pharmacogenomics, a domain where errors are measurable and sometimes...

Topics

Open a Topic to create a Post that cites this publication.

Genomics and Rare Diseases

Identifiers and source

Literature Corpus work: 0201c95f-8fa9-5958-94e0-2107c1399740
DOI: 10.64898/2026.06.11.731523

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trustworthy agentic genomics through versioned skill librariesDOI 10.64898/2026.06.11.731523Read

Benchmarking large language models for ACMG/AMP variant interpretation and variant callingSemantic proximity Read

Scoping Review: Explainable AI in Rare Disease GenomicsSemantic proximity Read

Trustworthy Agentic AI: A Rapid, PRISMA-Informed Evidence Review of Safety, Explainability, Alignment, and Human Oversight in Autonomous AI SystemsSemantic proximity Read

An auditable, retrieval-grounded agent architecture improves medical accuracy and conversational safety in language modelsSemantic proximity Read

Grounding Health AI: Architecture and Evaluation of a Domain-Expert Metabolic Health AgentSemantic proximity Read

ClinAgent: A Five-Layer Architecture for Autonomous Clinical Trial Statistical ProgrammingSemantic proximity Read

AIVA: An Agentic Platform for Phenotype-Aware Variant Analysis, Interpretation and Clinical Decision Support in Rare DiseaseSemantic proximity Read

PantheonOS: An Evolvable Multi-Agent Framework for Automatic Genomics DiscoverySemantic proximity Read

Evaluating open LLMs for agentic analysis orchestration in a typical biomedical labSemantic proximity Read

Agentic GenAI for Infectious Disease Management: A Comprehensive ReviewSemantic proximity Read

BiomniBench: Process-level Evaluation of LLM Agents for Real-world Biomedical ResearchSemantic proximity Read

Towards Human-Led, Agent-Driven Autonomous Laboratories for the Life SciencesSemantic proximity Read