Article

Longitudinal whole transcriptomic profiling of live cells through domain adaptation

2026-08-13

Abstract excerpt

Tracking transcriptomic profiles of cells over time in response to developmental cues and environmental stimuli can reveal critical insights into the fundamental mechanisms of development and disease. However, longitudinal molecular profiling at the global transcriptome level remains a major challenge, as RNA sequencing fundamentally alters or destroys cells. To overcome these limitations, we developed PENNE, a de...

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Literature Corpus work: 14e4e591-331f-50c8-93bc-2a638b637ba0
DOI: 10.64898/2026.08.07.743564

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