Article

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf War Illness diagnosis

2023-04-26

Abstract excerpt

<h4>Introduction: </h4> Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 143c0e74-1817-5fbd-8115-8e81743cdae7
DOI: 10.21203/rs.3.rs-2810223/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf War Illness diagnosisDOI 10.21203/rs.3.rs-2810223/v1Read

Gene–Toxicant Interactions in Gulf War Illness: Differential Effects of the PON1 GenotypeSemantic proximity Read

Butyrylcholinesterase genotype and enzyme activity in relation to Gulf War illness: preliminary evidence of gene-exposure interaction from a case-control study of 1991 Gulf War veterans.Semantic proximity Read

Genomic interplay between deployment exposures and Gulf War illness in Million Veteran Program participants.Semantic proximity Read

A Neuroimmune Model of Gulf War IllnessSemantic proximity Read

Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans.Semantic proximity Read

Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders.Semantic proximity Read

Evaluation of a Gene-Environment Interaction of PON1 and Low-Level Nerve Agent Exposure with Gulf War Illness: A Prevalence Case-Control Study Drawn from the U.S. Military Health Survey's National Population Sample.Semantic proximity Read

Prevalence of Mild and Severe Cognitive Impairment in World Trade Center Exposed Fire Department of the City of New York (FDNY) and General Emergency RespondersSemantic proximity Read

Genetic and epigenetic analysis implicates central myelin as a major target of Gulf War illnessSemantic proximity Read

Veteran-derived cerebral organoids display multifaceted pathological defects in studies on Gulf War IllnessSemantic proximity Read

Association of APOE ε4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults.Semantic proximity Read

APOE ε4 allele modifies the associations of toxic metals and their mixture with cognitive impairment among older adults.Semantic proximity Read