Article

Analysis of <i>DICER1</i> in familial and sporadic cases of Transposition of the Great Arteries

2017-04-07

Abstract excerpt

<h4>Background</h4> DICER1 plays a major role in development and in generating mature microRNAs that are important in gene expression. We screened for DICER1 mutations in a family with DICER1 syndrome and we discovered a pathogenic mutation in a child with transposition of the great arteries (TGA). In view of a report linking DICER1 knock-out in murine cardiomyocytes to cardiac outflow defects, we investigated...

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Literature Corpus work: 1372a685-68de-537e-bdd5-7b57da6e3225
DOI: 10.1101/125633

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