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Article

Exome-Based Case-Control Analysis Highlights the Pathogenic Role of Ciliary Genes in Transposition of the Great Arteries.

Circulation research - 27 Mar 2020

Liu Xuanyu, Chen Wen, Li Wenke, Priest James R, Fu Yuanyuan, Pang Kunjing, Ma Baihui, Han Bianmei, Liu Xuewen, Hu Shengshou, Zhou Zhou

Abstract excerpt

RATIONALE: Transposition of the great arteries (TGA) is one of the most severe types of congenital heart diseases. Understanding the clinical characteristics and pathogenesis of TGA is, therefore, urgently needed for patient management of this severe disease. However, the clinical characteristics and genetic cause underlying TGA remain largely unexplored. OBJECTIVE: We sought to systematically examine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32078439
DOI: 10.1161/CIRCRESAHA.119.315821

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