Article

Febuxostat Reduces Muscle Wasting in Tumor-bearing Mice via Inhibition of Reacrive Oxygen Species Generation

2020-05-04

Abstract excerpt

<title>Abstract</title> <p>Background To analyze the effects of the administration of febuxostat, a selective xanthine oxidase (XO) inhibitor, on both <italic>in vitro</italic> and <italic>in vivo</italic> models of the waste of skeletal muscles, due to LM8 osteosarcoma cells. Methods C2C12 myotubes were incubated in the conditioned medium of LM8 osteosarcoma cells. At the same time, febuxostat was added at a c...

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Literature Corpus work: 13668004-d0c0-5d97-aeaf-efb7cb610465
DOI: 10.21203/rs.3.rs-25212/v1

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