Article
Prelamin A in an Lmna L648R/L648R Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2026
Wang Yuexia, Joseph Leroy C, Östlund Cecilia, Kuriakose George, Hsu Wei, Michaelis Susan, Worman Howard J
Abstract excerpt
BACKGROUND: Hutchinson-Gilford progeria syndrome is an accelerated aging disorder characterized by numerous symptoms, including early onset atherosclerosis, myocardial infarctions, and strokes. Hutchinson-Gilford progeria syndrome is caused by mutations in LMNA that lead to expression of an internally truncated, farnesylated prelamin A variant called progerin, which induces loss of vascular smooth muscle cells....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.