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Article

New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome.

Human molecular genetics - 15 Mar 2014

Jung Hea-Jin, Tu Yiping, Yang Shao H, Tatar Angelica, Nobumori Chika, Wu Daniel, Young Stephen G, Fong Loren G

Abstract excerpt

Lamins A and C (products of the LMNA gene) are found in roughly equal amounts in peripheral tissues, but the brain produces mainly lamin C and little lamin A. In HeLa cells and fibroblasts, the expression of prelamin A (the precursor to lamin A) can be reduced by miR-9, but the relevance of those cell culture studies to lamin A regulation in the brain was unclear. To address this issue, we created two new Lmna...

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Identifiers

PMID: 24203701
DOI: 10.1093/hmg/ddt537
PMCID: PMC3929089

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome.PMID 24203701Read ↗

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